WebBisphosphonates (BP) are synthetic compounds with a common phosphorus-carbon-phosphorus bond and have a high affinity for the calcium hydroxyapatite of the bone. ... In the long-term (5-6 years), alendronate and zoledronic acid have been shown to continuously increase BMD at the lumbar spine, but not at the hip where BMD reaches a … WebOct 20, 2015 · Other common side effects include: Bone or joint pain, or generalized pain. Muscle cramps or aches. Nausea, constipation, diarrhea, or other stomach discomfort. Headache or dizziness. Head colds ...
Effects of Teriparatide in Patients with Osteoporosis in Clinical ...
WebJun 21, 2012 · In addition, serious side effects in the studies, although rare, included atypical leg fractures, osteonecrosis of the jaw, and esophageal cancer. All bisphosphonates approved for osteoporosis treatment have been effective in preventing fractures in trials lasting 3 to 4 years, the FDA researchers noted. WebUncommon side effects that have been noted with wide clinical use include osteonecrosis of the jaw, musculoskeletal complaints, and atypical fractures. The numbers of events are small, and a clear cause-and-effect relationship between these events and bisphosphonate treatment has not been established. safeway 13th avenue pharmacy
Bisphosphonates - Warnings, Precautions, Side Effects & Interactions
WebThe main side effects associated with bisphosphonates include: irritation to the food pipe swallowing problems stomach pain Osteonecrosis of the jaw is a rare side effect linked with the use of bisphosphonates, although most frequently with high-dose intravenous bisphosphonate treatment for cancer and not for osteoporosis. WebWhat are the adverse effects of bisphosphonates? Adverse effects of oral bisphosphonates include: Gastrointestinal (most common) — nausea, dyspepsia, mild gastritis, and abdominal pain. They are more likely to occur in the first month of treatment. Bone, joint, and/or muscle pain (common). WebHowever, bone-specific side effects of cancer therapies can have a negative effect on patients’ long-term bone health. The accelerated bone loss associated with BC therapies, especially endocrine therapy, can put women at risk for osteoporosis and fractures later in life. ... Bisphosphonates have long been used to treat osteoporosis, as well ... they found that the principal