WebThe mechanisms that allow cells to use iron safely are not clear; defects in iron management are a causative factor in the cell‐death pathway known as ferroptosis. Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells. Web1997)+ Poly(rC) binding proteins 1 and 2 form a UV-light induced covalent bond with nt 24 of the 59-terminal cloverleaf of poliovirus RNA (Andino et al+, 1993)+ In a second ribonucleoprotein complex, both poly(rC) bind-ing protein(s) and viral protein 3CD bind to the 59-terminal cloverleaf structure (Gamarnik &Andino,1997;
PCBP3 poly(rC) binding protein 3 [ Homo sapiens (human) ]
WebJun 14, 2024 · Poly(rC)-binding protein 1 (PCBP1) is a multifunctional protein that coordinates both RNA and iron. PCBP1 was initially identified as a component of … WebFeb 28, 2024 · 17 and microRNAs – to complete its viral life cycle. The cellular RNA-binding protein poly(rC)-18 binding protein 1 (PCBP1) had previously been reported to bind the HCV genome 5´ 19 untranslated region (UTR), but its importance in the viral life cycle has remained unclear. 20 Herein, we aimed to clarify the role of PCBP1 in the HCV life cycle. the passion 2021 cast
Advances in poly(rC)-binding protein 2: Structure
Webpoly(rC) binding protein 3. Synonyms. AlphaCP-3 Feature Type. protein coding gene. IDs. MGI:1890470 NCBI Gene: 59093. Alliance. gene page. Transcription Start Sites. 7 TSS. Location & Maps more. Sequence Map Chr10:76597691-76797721 bp, - strand. From Ensembl annotation ... WebWith the exception of 5 amino acid differences, the mouse and human proteins are identical. PCBP3 contains 2 KH (HNRNPK ( 600712 )-homology) domains in the N-terminal half, and … WebOct 16, 2008 · Recombinant hnRNP K-homology (KH) domains 1 and 3 of the poly(rC)-binding protein (PCBP) 2 were purified and assayed for interaction with coxsackievirus B3 RNA in electrophoretic mobility shift assays using in vitro transcribed RNAs which represent signal structures of the 5'-nontranslated region. shweta chaubey attorney